Caryophyllene oxide (C15H24O) is a white, crystalline sesquiterpene compound derived from the oxidation of B-caryophyllene, commonly found in cannabis, cloves, lemon balm, and basil. It is widely used in fragrances and flavors for its woody, spicy, and dry scent, and is known for its anticancer, antimicrobial, and anti-inflammatory properties.

Caryophyllene oxide (C15H24O) Key Characteristics:

Aroma & Appearance: It presents as white crystals with a sweet, woody aroma and fresh spicy undertones.

Source: It is a major component in various essential oils, including eucalyptus and clove, and is produced when \(\beta \)-caryophyllene oxidizes during the curing of plant materials.

Caryophyllene oxide (C15H24O) Primary Applications:

Food Flavoring: Seasonings, baked goods, meat products, beverages, confectionery, alcoholic drinks
Daily Chemicals (Fixative): Perfumes, skincare products, oral care, home fragrances
Pharmaceutical Research: Anti-inflammatory, anti-cancer, anti-fungal, skin penetration enhancer
Natural Preservative: Bacteriostatic concentration required is merely 0.5 mg/mL

Usage Reference:

Food Flavor Formulation: 2 ~ 200 mg/kg
Cosmetics: Used as a middle-to-base note fixative to enhance fragrance longevity

Caryophyllene oxide (C15H24O) Crystalline Powder Pharmacological

Caryophyllene oxide (C15H24O) Crystalline Powder Pharmacological Effects and Benefits:

Anti-inflammatory and Analgesic: Exhibits significant anti-inflammatory activity, capable of reducing skin inflammatory responses (such as rosacea). Studies also indicate that it can enhance the analgesic effects of acetaminophen and possesses gastroprotective properties.

Antifungal and Antibacterial: Highly effective against certain microbial strains; frequently used in the treatment of nail fungus and other cutaneous fungal infections.

Anticancer Potential: Considered a potent anti-tumor agent, capable of inhibiting various cancer cell lines by modulating cellular growth and proliferation pathways (e.g., the STAT3 pathway).

Cardiovascular and Systemic Regulation: Exerts a relaxant effect on smooth muscle tissue and acts as a calcium channel blocker, thereby demonstrating potential for use as an adjunct therapy in the management of hypertension.

Synergistic Effects: Within botanical matrices (such as cannabis), the “Entourage Effect”—arising from its interaction with other constituent compounds—is believed to enhance the overall therapeutic efficacy.

Caryophyllene oxide (C15H24O) Key Advantages:

High Heat Stability (279–301°C) — Suitable for high-temperature processes such as baking
Aroma Fixation & Enhancement — Extends the complexity and longevity of the fragrance
Natural Preservative & Antioxidant — Aligns with “Clean Label” trends
High Efficacy at Low Dosage — As little as 0.01% can enhance the lingering aftertaste of citrus beverages

Caryophyllene oxide (C15H24O) Safety and Specifics:

Toxicity: It is generally considered non-toxic and non-sensitizing.

Interaction: Unlike B-caryophyllene, which directly binds to CB2 receptors, caryophyllene oxide acts differently, according to some studies.

Synthesis: It is produced through the oxidation of B-caryophyllene.

Storage:

Store in a sealed container, away from light, in a cool and dry place (recommended temperature: 6–8°C). As the product is prone to oxidation, it requires strict airtight sealing.